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Transmembrane protein 251 : ウィキペディア英語版 | Transmembrane protein 251
Transmembrane protein 251, also known as C14orf109 or UPF0694, is a protein that in humans is encoded by the TMEM251 gene. One notable feature of this protein is the presence of proline residues on one of its predicted transmembrane domains.,〔 which is a determinant of the intramitochondrial sorting of inner membrane proteins. == Gene == The TMEM251 gene is located on human chromosome 14, at 14q32.12, on the plus strand. The gene size is 1,277 base pairs. It contains 3 distinct introns, and transcription produces six different mRNAs that appear to differ by truncation of the 3' end. There are 2 transcript variants that encode for the TMEM251 protein, with the longer one being 169 base pairs in length, and the shorter one being 131 base pairs in length. The first transcript variant encodes a shorter predicted protein, while the second transcript variant encodes a protein with a longer N-terminus. Both consists of two exons that include the entire coding sequence for the TMEM251 protein.〔 TMEM251 chromosome location ''Figure 1'': Chromosome 14 overview. TMEM251 is positioned at 14q32.12, marked by a red line.
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